Research Article |
Corresponding author: Wojciech Ciesielski ( w.ciesielski@interia.pl ) Academic editor: Josef Settele
© 2022 Wojciech Ciesielski, Tomasz Girek, Zdzisław Oszczęda, Jacek A. Soroka, Piotr Tomasik.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation:
Ciesielski W, Girek T, Oszczęda Z, Soroka JA, Tomasik P (2022) Potential risk resulting from the influence of static magnetic field upon living organisms. Numerically simulated effects of the static magnetic field upon metalloporphyrines. BioRisk 18: 115-132. https://doi.org/10.3897/biorisk.18.86616
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Background: An attempt to recognize the effects of a static magnetic field (SMF) of varying flux density on flora and fauna.. For this purpose the influence of static magnetic field upon molecules of Mg(II), Fe(II), Fe(III), Co(II), Co(III) and Cu(II) metalloporphyrins is studied.
Methods: Computations of the effect of real SMF 0.0, 0.1, 1, 10 and 100 AFU (Arbitrary Magnetic Field Unit; here 1AMFU > 1000 T) flux density were performed in silico (computer vacuum) involving advanced computational methods.
Results: The static magnetic field (SMF) decreased the stability of the metalloporphyrine molecules. This effect depended on the situation of the molecule in respect to the direction of the SMF of the Cartesian system. An increase in the value of heat of formation was accompanied by an increase in the dipole moment. It was an effect of deformations of the molecule which involved pyrrole rings holding the hydrogen atoms at the ring nitrogen atoms and the length of the C-H and N-H bonds. As a consequence, that macrocyclic ring lost its planarity.
Conclusions: SMF even of the lowest, 0.1 AMFU flux density influences the biological role of metalloporphyrines associated with their central metal atoms. This effect is generated by changes in the electron density at these atoms, its steric hindering and polarization of particular bonds from pure valence bonds possibly into ionic bonds.
Co(II)porphyrine, Co(III)porphyrine, Cu(II)porphyrine, Fe(II)porphyrine, Fe(III)porphyrine, Mg(II)porphyrine
Our previous paper (
In metalloporphyrines holding either Fe(II), Fe(III), Co(II), Co(III) or Cu(II) these central atoms of the complexes act as coordination sites. Porphine derivatives with Fe(II) and Fe(III) ions coordinated and chemically bound within the macrocyclic ring are called hem and hemin, respectively. They are red-coloured compounds constituting the animal and human blood. Ferrous cation in heme can coordinate such as molecular oxygen, carbon monoxide, cyanide anion and other ligands. In hemin Fe(III) atom utilizes one of its valence bonds for binding chlorine atom. It is formed from a hem group, such as hem B found in the hemoglobin of human blood (
Porphine derivatives coordinated to the Co(II) and Co(III) ions are known as vitamin B12, (cobalamin). It is a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. It is essential for the normal functioning of the nervous system and the maturation of red blood cells in the bone marrow (
In the organisms of some invertebrates such as snails, lobsters and spiders, oxygen is transported by hemicyanines containing Cu(II) atom instead of Fe(II)/Fe(III) ions. Such hemocyanines (hemolymph) carrying coordinated oxygen are blue colored. Hence these invertebrates have blue blood (
Recently, numerous synthetic derivatives of the parent porphine in the form of metalloporhyrines have found their application in the material sciences of engineering, chemistry, physics, biology, and medicine (
The subject of this paper focuses on the effect of SMF of 0.1 to 100 AMFU (Arbitrary Magnetic Field Unit) upon Mg (II), Fe(II), Fe(III), Co(II), Co(III), and Cu(II) porphyrines as the most essential and most common in functioning organisms of flora and fauna. The target is achieved involving in silico (computer vacuum) advanced computational methods.
DFT (Density Functional Theory) Molecular structures were drawn using the Fujitsu Scigress 2.0 software (
Z axis is perpendicular to the porphine plane, the x and y axes are in the plane of the system, each of them along two nitrogen atoms. Because of mesomerism only, due to quaternary symmetry z axis the last two axes are undistinguished and symmetry D4h is observed (
Subsequently, involving Gaussian 0.9 software equipped with the 6–31G** basis (
In the consecutive step, influence of static magnetic field (SMF) upon optimized molecules were computed with Amsterdam Modelling Suite software (
Visualization of the HOMO/LUMO orbitals and changes of the electron density for particular molecules and their three molecule systems were performed involving the HyperChem 8.0 software (
Fig.
Based on the criterion of values of heat of formation (the stability of the system increases with declining negative value) (Table
Heat of formation [kJ.mol-1] and dipole moment [D] of the metalloporphyrine molecules depending on applied SMF flux density [AMFU] and their situating in the Cartesian system.
SMF along indicated Cartesian axis | Heat of formation [kJ·mol-1] at SMF flux density [AMFU] | Dipole moment [D] at SMF flux density [AMFU] | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | 0 | 0.1 | 1.0 | 10 | 100 | |
Mg(II) | ||||||||||
X | -803 | -781 | -772 | -731 | -698 | 2.06 | 2.10 | 2.15 | 2.19 | 2.31 |
Z | -799 | -794 | -771 | -726 | 2.09 | 2.10 | 2.11 | 2.18 | ||
Y | -796 | -781 | -762 | -716 | 2.10 | 2.14 | 2.20 | 2.29 | ||
Fe(II) | ||||||||||
X | -982 | -972 | -953 | -911 | -875 | 1.99 | 2.03 | 2.10 | 2.24 | 2.41 |
Z | -979 | -967 | -932 | -904 | 2.01 | 2.06 | 2.11 | 2.24 | ||
Y | -979 | -964 | -936 | -906 | 2.03 | 2.11 | 2.16 | 2.34 | ||
Fe(III)+ | ||||||||||
X | -1125 | -1038 | -987 | -894 | -815 | 2.06 | 2.11 | 2.19 | 2.35 | 2.62 |
Z | -1097 | -1005 | -974 | -897 | 2.09 | 2.15 | 2.19 | 2.31 | ||
Y | -1023 | -1000 | -971 | -902 | 2.11 | 2.24 | 2.32 | 2.62 | ||
Co(II) | ||||||||||
X | -969 | -942 | -918 | -781 | -743 | 2.03 | 2.09 | 2.22 | 2.38 | 3.24 |
Z | -952 | -947 | -932 | -918 | 2.06 | 2.15 | 2.21 | 2.38 | ||
Y | -946 | -923 | -761 | -694 | 2.09 | 2.23 | 2.59 | 3.48 | ||
Co(III)+ | ||||||||||
X | -1021 | -1014 | -997 | -876 | -831 | 2.03 | 2.09 | 2.22 | 2.38 | 3.04 |
Z | -1006 | -985 | -934 | -858 | 2.06 | 2.13 | 2.25 | 2.32 | ||
Y | -1015 | -995 | -968 | -885 | 2.08 | 2.23 | 2.42 | 2.97 | ||
Cu(II) | ||||||||||
X | -921 | -892 | -871 | -811 | -752 | 2.01 | 2.06 | 2.15 | 2.39 | 2.68 |
Z | -918 | -906 | -893 | -812 | 2.03 | 2.06 | 2.09 | 1.98 | ||
Y | -885 | -872 | -803 | -711 | 2.06 | 2.17 | 2.51 | 3.69 |
Fe(III)+ > Co(III)+ > Fe(II) > Co(II) > Cu(II) > Mg(II)
SMF destabilized the Mg(II)porphyrine. The value of heat formation gradually turned into less negative against an increase in applied flux density (Table
In Mg(II)porphyrine (Fig.
Deformation of Mg(II) porphyrine in SMF of 0 – 100 AMFU when the SMF direction is in (a–c) along X, Z and Y axes, respectively.
The shape of the porphyrin skeleton differed from the flat one characterized by the point group D4h. It took the shape of a dome typical for the point group A2u. The increase in SMF ejected the magnesium atom from the center of the molecule because of increasing lengths of the Mg-N bonds.
Corresponding variations of the charge density on the N- and Mg(II) atoms and the Mg(II)-N bond lengths are reported in Tables
Charge density [a.u] at particular atoms of the Mg(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | -0.219 | -0.095 | -0.045 | -0.297 | -0.021 |
Z | -0.212 | -0.122 | -0.118 | -0.083 | ||
Y | -0.067 | -0.135 | -0.249 | -0.153 | ||
N3 | X | -0.197 | -0.192 | -0.122 | -0.255 | -0.037 |
Z | 0.051 | 0.179 | 0.167 | 0.172 | ||
Y | -0.167 | -0.174 | -0.218 | -0.136 | ||
Mg37 | X | 0.387 | 0.637 | 0.638 | 0.538 | 0.532 |
Z | 0.521 | 0.546 | 0.556 | 0.577 | ||
Y | 0.626 | 0.640 | 0.567 | 0.646 |
Data in Table
In their character the Mg-N bonds were intermediate between ionic and atomic, making the binding electron pair essential. Under the influence of a high external SMF, the durability of such a pair, maintained by magnetic forces, decreased. Thus, the bond become weaker and longer (Table
Bond lengths [Ǻ] between particular atoms of the Mg(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1-Mg37 | X | 1.917 | 2.161 | 2.286 | 2.125 | 2.438 |
Z | 2.111 | 2.045 | 2.077 | 2.156 | ||
Y | 2.096 | 2.140 | 2.066 | 2.136 | ||
N3-Mg37 | X | 1.898 | 2.169 | 2.298 | 1.944 | 2.459 |
Z | 2.109 | 2.061 | 2.090 | 2.126 | ||
Y | 2.106 | 2.126 | 1.910 | 1.155 |
The criterion of the heat of formation of Fe(II)porphyrine and Fe(III)porphyrine indicated that SMF destabilized these molecules.
The Fe(II) atom in Fe(II)porhyrine was tetracoordinated (Fig.
Deformation of Fe(II)porphyrine in SMF of 0 – 100 AMFU when SMF direction is in (a–c) along X, Z and Y axes, respectively.
Already out of SMF the molecule was non-planar and SMF considerably contributed to its deformation. In the molecule situated in the X-Y plane, particularly at 10 and 100 AMFU, remarkable charge density (Table
Charge density [a.u.] at particular atoms of the Fe(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | -0.408 | -0.379 | -0.425 | -0.252 | -0.123 |
Z | -0.384 | -0.385 | -0.375 | 0.004 | ||
Y | -0.408 | -0.425 | -0.488 | -0.439 | ||
N3 | X | -0.346 | -0.397 | -0.315 | -0.249 | -0.199 |
Z | -0.350 | -0.325 | -0.336 | 0.165 | ||
Y | -0.501 | -0.503 | -0.438 | -0.497 | ||
Fe37 | X | 1.651 | 1.602 | 1.473 | 1.212 | 1.039 |
Z | 1.734 | 1.685 | 1.661 | 1.019 | ||
Y | 1.845 | 1.823 | 1.822 | 1.769 |
An elongation of the Fe-N was much less remarkable than that observed in Mg(II)porphyrine (Table
Bond lengths [Ǻ] between particular atoms of the Fe(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N2-Fe37 | X | 1.893 | 1.994 | 2.170 | 2.047 | 2.109 |
Z | 1.730 | 1.794 | 1.770 | 1.787 | ||
Y | 1.782 | 1.658 | 1.763 | 1.801 | ||
N3-Fe37 | X | 1.898 | 1.926 | 2.170 | 2.214 | 2.644 |
Z | 1.855 | 1.840 | 1.860 | 1.885 | ||
Y | 1.689 | 1.692 | 1.738 | 1.772 |
The Fe(III) atom of Fe(III)porhyrine cation was also tetra-coordinated. Deformations of the molecules by increasing flux density are presented in Fig.
Deformation of Fe(III)porphyrine in SMF of 0 – 100 AMFU when the SMF direction is in (a–c) along X, Z and Y axes, respectively.
Compared to Fe(II)porphirine the porphine skeleton localized along X and Z axes faced only slight deformation evoked by SMF.
Relevant charge density at particular atoms and bond lengths are collected in Tables
Charge density [a.u.] at particular atoms of the Fe(III)porphyrine molecule cation depending on SMF flux density [AMFU] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | -0.354 | -0.457 | -0.465 | -0.437 | -0.065 |
Z | -0.430 | -0.382 | -0.403 | -0.423 | ||
Y | -0.455 | -0.452 | -0.057 | -0.082 | ||
N3 | X | -0.363 | -0.400 | -0.395 | -0.329 | -0.073 |
Z | -0.352 | -0.385 | -0.396 | -0.414 | ||
Y | -0.451 | -0.441 | -0.149 | -0.121 | ||
Fe37 | X | 1.696 | 1.767 | 1.765 | 1.429 | 0.928 |
Z | 1.654 | 1.726 | 1.765 | 1.807 | ||
Y | 1.787 | 1.797 | 1.154 | 1.199 |
An increase in applied SMF resulted in an irregular change of the positive charge density of the Fe atom. A general tendency in decrease of that charge was perturbed mainly in the molecules oriented against SMF along Z-axis. The same effect could be observed for negative charge density at the N1 and N3 atoms which, generally, decreased with an increase in applied SMF (Table
Such irregularities were accompanied with irregular changes of the N-Fe bond lengths. These bonds generally were elongated with an increase in applied SMF (Table
Bond lengths [Ǻ] between particular atoms of the Fe(III)porphyrine molecule cation depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1-Fe37 | X | 1.917 | 1.802 | 1.820 | 1.997 | 2.173 |
Z | 1.905 | 1.828 | 1.886 | 1.803 | ||
Y | 1.822 | 1.835 | 1.912 | 1.945 | ||
N3-Fe37 | X | 1.873 | 1.823 | 1.809 | 2.140 | 2.126 |
Z | 1.950 | 1.807 | 1.796 | 1.723 | ||
Y | 1.897 | 1.798 | 1.863 | 1.835 |
An insight in Table
The Co(II) atom in Co(II)porphyrine remained bidentate. Its presence inhibited to a great extent the deformation of the molecule involving bending molecule typical for formerly mentioned metalloporphyrines (Fig.
Deformation of Co(II) porphyrine in SMF of 0 – 100 AMFU when the SMF direction is in (a–c) along X, Z and Y axes, respectively.
The SMF acting along the Z- axis flatted the molecule. The increase in SMF changed the conformations in the order: dome-flat-flat-dome with simultaneous distancing of the cobalt atom from the plane of the molecule.
The action of SMF along the X or Y axis evoked a wave mode deformation, with a point group Egx,y (
The applied SMF atom always affected the negative charge density at the N-atoms and positive charge density at the Co-atom. These changes were chimerically dependent on the orientation of the molecules against SMF (Table
Charge density [a.u] at particular atoms of the Co(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | -0.218 | -0.094 | -0.247 | -0.149 | -0.059 |
Z | -0.226 | -0.118 | -0.144 | 0.085 | ||
Y | -0.214 | -0.281 | -0.190 | -0.129 | ||
N3 | X | -0.220 | -0.149 | -0.164 | -0.259 | -0.288 |
Z | -0.034 | -0.160 | -0.126 | -0.227 | ||
Y | -0.201 | -0.254 | -0.094 | 0.131 | ||
Co37 | X | 0.509 | 0.584 | 0.705 | 0.611 | 0.878 |
Z | 0.587 | 0.596 | 0.574 | 0.467 | ||
Y | 0.605 | 0.754 | 0.596 | 0.971 |
The SMF also influenced and extended the length of both N-Co bonds and that effect was strongly dependent on the orientation of the molecule against the SMF (Table
Bond lengths [Ǻ] between particular atoms of the Co(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1-Co37 | X | 1.958 | 2.054 | 2.138 | 2.224 | 2.202 |
Z | 2.011 | 2.064 | 1.889 | 1.925 | ||
Y | 2.113 | 2.323 | 2.450 | 2.406 | ||
N3-Co37 | X | 1.945 | 2.036 | 2.123 | 2.142 | 2.394 |
Z | 2.139 | 2.052 | 1.090 | 1.892 | ||
Y | 1.862 | 2.230 | 1.926 | 2.745 |
The Co(III) atom in Co(III)porphyrine cation also remained bidentate and, principally, it also inhibited deformation of the molecule by bending. In comparison to Co(II) atom its presence in the macrocyclic ring favoured elongation of some C-H bonds to the extent suggesting their dissociation (Fig.
Deformation of Co(III)porphyrine in SMF of 0 – 100 AMFU when the SMF direction is in (a–c) along X, Z and Y axes, respectively.
The action of the SMF along each axis causes deformation of the flat system to corrugated, wave mode Egx,y (
The relevant changes of the charge density at Co and N atoms and the Co-N atom bonds are reported in Tables
Charge density [a.u] at particular atoms of the Co(III)porphyrine molecule cation depending on SMF flux density [AMFU] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | -0.243 | -0.205 | -0.048 | -0.052 | -0.017 |
Z | -0.223 | -0.200 | -0.200 | 0.034 | ||
Y | -0.303 | -0.378 | -0.303 | -0.252 | ||
N3 | X | -0.304 | -0.270 | -0.004 | -0.365 | 0.516 |
Z | -0.258 | -0.161 | -0.147 | 0.134 | ||
Y | -0.358 | -0.312 | -0.186 | -0.337 | ||
Co37 | X | 1.223 | 1.247 | 1.220 | 1.018 | 0.651 |
Z | 1.158 | 1.175 | 1.155 | 0.864 | ||
Y | 1.206 | 1.110 | 1.188 | 0.946 |
Bond lengths [Ǻ] between particular atoms of the Co(III)porphyrine molecule cation depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1-Co37 | X | 2.052 | 2.181 | 2.471 | 1.979 | 2.497 |
Z | 2.053 | 1.899 | 1.859 | 1.867 | ||
Y | 2.049 | 1.892 | 1.967 | 1.930 | ||
N3-Co37 | X | 2.064 | 2.069 | 1.972 | 1.588 | 2.221 |
Z | 2.106 | 1.910 | 1.921 | 1.956 | ||
Y | 2.027 | 1.646 | 1.961 | 1.779 |
Deformation of Cu(II)porphyrine in SMF of 0 – 100 AMFU when the SMF direction is in (a–c) along X, Z and Y axes, respectively.
SMF negatively perturbs biological functions of Cu(II)porphyrine as it increased its heat of formation (Table
Inserting the Cu(II) atom into the porphine ring produced its deformation by bending already out of SMF.
An increase in SMF caused a change in conformation from the dome to the flat one. It distinguished Cu(II)porphyrine from those discussed above. The presence of the Cu(II) atom favored considerable elongation of the C-H bonds.
Charge density distribution in this molecule and relevant bond lengths are grouped in Tables
Performed computations presented fairly unusual effects of insertion of Cu(II) atom into porphine. Thus, already in the molecule out of SMF both nitrogen atoms bound to the Cu(II) atom hold the positive charge density. Already SMF of flux density of 0.1 AMFU turned the charge density at the N1 atom into negative when the molecule was oriented along either X or Z axis. In the molecule oriented along the Y axis just the flux density of 100 AMFU developed negative charge density at that atom. The N3 atom appeared to be more susceptible to the conversion of its initial positive charge density into negative. In the molecule located along the X axis solely flux density of 0.1 AMFU could not convert that charge density into negative. In all remained cases the charge density at that atom readily converted into negative.
Applied SMF invariantly increased positive charge density at the Cu atom (Table
Charge density [a.u] at particular atoms of the Cu(II)porphyrine molecule depending on SMF flux density [T] situating in the Cartesian system.
Atom | SMF along indicated Cartesian axis | Charge density [a.u] at SMF flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1 | X | 0.202 | -0.237 | -0.259 | -0.534 | -0.473 |
Z | -0.235 | -0.260 | -0.248 | -0.202 | ||
Y | 0.109 | 0.054 | 0.012 | -0.241 | ||
N3 | X | 0.040 | 0.061 | -0.227 | -0.465 | -0.413 |
Z | -0.137 | -0.258 | -0.165 | -0.124 | ||
Y | -0.160 | -0.084 | -0.120 | -0.302 | ||
Cu37 | X | 0.726 | 0.907 | 0.814 | 0.962 | 0.942 |
Z | 0.967 | 1.003 | 1.076 | 0.911 | ||
Y | 0.847 | 0.790 | 0.882 | 0.993 |
Bond lengths [Ǻ] between particular atoms of the Cu(II)porphyrine molecule depending on SMF flux density [AMFU] situating in the Cartesian system.
Bond | SMF along indicated Cartesian axis | Bond length [Ǻ] at flux density [AMFU] | ||||
---|---|---|---|---|---|---|
0 | 0.1 | 1.0 | 10 | 100 | ||
N1-Cu37 | X | 1.964 | 1.649 | 1.437 | 2.046 | 1.991 |
Z | 1.962 | 1.975 | 2.058 | 1.947 | ||
Y | 2.213 | 1.932 | 2.243 | 2.884 | ||
N3-Cu37 | X | 1.966 | 2.166 | 2.172 | 1.836 | 1.860 |
Z | 1.956 | 1.961 | 2.045 | 2.032 | ||
Y | 2.044 | 2.060 | 2.132 | 2.483 |
Thus, in summary, static magnetic field (SMF) decreased stability of the metalloporphyrine molecules. This effect depended on the situating of the molecule in respect to the direction of SMF of the Cartesian system. An increase in the value of heat of formation was accompanied by an increase in dipole moment. It was an effect of deformations of the molecule which involved pyrrole rings holding the hydrogen atoms at the ring nitrogen atoms and the length of the C-H and N-H bonds. As a consequence that macrocyclic ring lost its planarity. Recently, (
SMF even of the lowest, 0.1 AMFU flux density influences the biological role of metalloporphyrines associated with their central metal atoms. This effect is generated by changes in the electron density at these atoms, its steric hindering and polarization of particular bonds from pure valence bonds possibly into ionic bonds. Regardless of its situation along x, y and z axis, SMF always destabilized the metalloporphyrine molecules. Evoked deformation of particular molecules facilitated additional ligation of the central metal atom. Potentially, this effect could be used in synthetic modifications of metalloporphyrines.